Autism Research and Treatment · 2015 · 98 citations · 49 references
EducationPediatricsSpecial EducationAutism Spectrum DisordersChild DevelopmentEarly InterventionChild Behavior InterventionCommunication DevelopmentEarly Language DevelopmentFamily-centered InterventionLanguage InterventionSocial-emotional InterventionAutism Spectrum Disorder InterventionAutism Spectrum Disorder ReferralAutism Spectrum Disorder ScreeningEarly Autism InterventionModel Fit ComparisonParent-implemented InterventionParental ResponsivenessReceptive Language Intervention
This study examined the (a) feasibility of enrolling 12-month-olds at risk of ASD from a community sample into a randomized controlled trial, (b) subsequent utilization of community services, and (c) potential of a novel parent-mediated intervention to improve outcomes. The First Year Inventory was used to screen and recruit 12-month-old infants at risk of ASD to compare the effects of 6-9 months of Adapted Responsive Teaching (ART) versus referral to early intervention and monitoring (REIM). Eighteen families were followed for ~20 months. Assessments were conducted before randomization, after treatment, and at 6-month follow-up. Utilization of community services was highest for the REIM group. ART significantly outperformed REIM on parent-reported and observed measures of child receptive language with good linear model fit. Multiphase growth models had better fit for more variables, showing the greatest effects in the active treatment phase, where ART outperformed REIM on parental interactive style (less directive), child sensory responsiveness (less hyporesponsive), and adaptive behavior (increased communication and socialization). This study demonstrates the promise of a parent-mediated intervention for improving developmental outcomes for infants at risk of ASD in a community sample and highlights the utility of earlier identification for access to community services earlier than standard practice.
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Catherine Lord, Susan Risi, Linda Lambrecht et al. · Journal of Autism and Developmental Disorders · 2000 · 7.6K citations
Unusual brain growth patterns in early life in patients with autistic disorder
Christina M. Karns, Harvey Davis, R. Ziccardi et al. · Neurology · 2001 · 1.5K citations