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Presenilin-1 L166P Mutant Human Pluripotent Stem Cell–Derived Neurons Exhibit Partial Loss of γ-Secretase Activity in Endogenous Amyloid-β Generation

Neurodegenerative DiseasesInduced Pluripotent Stem CellMolecular NeuroscienceSynaptic SignalingMedicineStem Cell Engineeringγ-Secretase ActivityStem Cell ResearchProtein MisfoldingEndogenous Amyloid-β GenerationNeuroscienceStem Cell TherapiesStem Cell BiologyStem CellsCell BiologyNeural Stem CellSocial Sciences