The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

Lucía Chávez‐Gutiérrez, Leen Bammens, Iryna Benilova, +15

The EMBO Journal

Neurodegenerative Diseasesγ-Secretase DysfunctionAlzheimer's DiseaseDegenerative PathologyNeurology +4

Presenilin clinical mutations can affect γ‐secretase activity by different mechanisms

Mostafa Bentahir, Omar Nyabi, Jan Verhamme, +5

Journal of Neurochemistry

Neurochemical diagnosis of Alzheimer’s dementia by CSF Aβ42, Aβ42/Aβ40 ratio and total tau

Piotr Lewczuk, Hermann Esselmann, Markus Otto, +9

Neurobiology of Aging

Neurodegenerative DiseasesTotal TauAlzheimer's DiseaseDementiaCsf Aβ42 +10

Highly conserved and disease‐specific patterns of carboxyterminally truncated Aβ peptides 1–37/38/39 in addition to 1–40/42 in Alzheimer's disease and in patients with chronic neuroinflammation

Jens Wiltfang, Hermann Esselmann, Mirko Bibl, +10

Journal of Neurochemistry

γ-Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer’s Disease

Lutgarde Serneels, Jérôme Van Biervliet, Katleen Craessaerts, +18

Science

Protein SecretionMolecular BiologyNeurochemical BiomarkersAlzheimer's DiseaseDegenerative Pathology +17

Amyloid β peptide ratio 42/40 but not Aβ42 correlates with phospho‐Tau in patients with low‐ and high‐CSF Aβ40 load

Jens Wiltfang, Hermann Esselmann, Mirko Bibl, +16

Journal of Neurochemistry

Amyloid βNeurochemical BiomarkersAlzheimer's DiseaseDegenerative PathologyProtein Misfolding +18

CSF amyloid-β-peptides in Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease dementia

Mirko Bibl, Brit Mollenhauer, Hermann Esselmann, +9

Brain

Neurochemical BiomarkersSocial SciencesAbeta Peptide PatternAlzheimer's DiseaseAmyloid Plaques +18

Decreased β-amyloid _1-42 in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease

Markus Otto, Hermann Esselmann, Walter Schulz‐Schaeffer, +11

Neurology

Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: a multicenter study

Piotr Lewczuk, Heike Kamrowski‐Kruck, Oliver Peters, +24

Molecular Psychiatry

Neuroimaging BiomarkersAlzheimer's DiseaseMedicineCerebrospinal FluidBiomarkers +7

Combined CSF tau, p-tau181 and amyloid-β 38/40/42 for diagnosing Alzheimer’s disease

Volker Welge, Oliver Fiege, Piotr Lewczuk, +9

Journal of Neural Transmission

Neurodegenerative DiseasesCsf TauAlzheimer's DiseaseMedicineBiomarkers +10