Angewandte Chemie International Edition in English · 1994 · 119 citations · 21 references
Life SciencesBiochemistryMolecular BiologyEnzymologyNucleic Acid BiochemistryNucleic Acid ChemistryModified Nucleic AcidsNucleic Acid ModificationOligonucleotide ChemistryRibonucleic Acid (Rna) ChemistryRna CleavageRna ModificationAmide LinkersAmide ReplacementBackbone Modification SynthesisChemical Modification Of OligonucleotidesNucleic Acid Backbone ModificationOligonucleotide Backbone ModificationsPhosphodiester BackbonePhosphodiester Oligonucleotides
No decrease in the affinity for the complementary RNA target is observed when the natural phosphodiester linkages in oligonucleotides are replaced with amide units. This was found in investigations of oligonucleotides containing one or more modified components 1. In addition these oligonucleotides are roughly ten times more resistant towards 3′-exonucleases.
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New coupling reagents in peptide chemistry
Reinhard Knorr, Arnold Trzeciak, Willi Bannwarth et al. · Tetrahedron Letters · 1989 · 986 citations
N. D. SINHA, J. Biernat, J. F. A. McManus et al. · Nucleic Acids Research · 1984 · 848 citations · Full text