Concepedia

Backbone Modification Synthesis

Backbone Modification Synthesis is a methodological approach in nucleic acid chemistry that involves the systematic alteration of the phosphodiester backbone of nucleic acids to enhance stability, delivery, or functionality while preserving the informational capacity of the nucleobase sequence.

53

Publications

2.5K

Citations

220

Authors

72

Institutions

Publications per year

2017–2026

11

Parents

Publications

53

Expedient Total Synthesis of Small to Medium-Sized Membrane Proteins via Fmoc Chemistry

Ji‐Shen Zheng, Yu Mu, Yun‐Kun Qi et al. · Journal of the American Chemical Society · 2014 · 179 citations

, , +11

Some ‘difficult sequences’ made easy

Carolyn B. Hyde, T. Johnson, David Owen et al. · International journal of peptide & protein research · 1994 · 131 citations

, , +10

Backbone modification of a polypeptide drug alters duration of action in vivo

Ross W. Cheloha, Akira Maeda, Thomas Dean et al. · Nature Biotechnology · 2014 · 125 citations · Full text

, , +12

Some 'difficult sequences' made easy. A study of interchain association in solid-phase peptide synthesis.

Carolyn B. Hyde, T. Johnson, David Owen et al. · PubMed · 1994 · 124 citations

, , +8

Robust Chemical Synthesis of Membrane Proteins through a General Method of Removable Backbone Modification

Ji‐Shen Zheng, Yao He, Chao Zuo et al. · Journal of the American Chemical Society · 2016 · 120 citations

, , +12

1–5 of 53

Authors

220

  1. LL
    Lei Liu

    Tsinghua University, China

    7 publications · 535 citations

    7

    h-index

  2. JZ
    Ji‐Shen Zheng

    Tsinghua University, China

    6 publications · 524 citations

    6

    h-index

  3. ST
    Shan Tang

    Tsinghua University, China

    6 publications · 524 citations

    6

    h-index

  4. CT
    Changlin Tian

    University of Science and Technology of China, China

    5 publications · 471 citations

    5

    h-index

  5. BK
    Bernhard Koppenhoefer

    University of Tübingen, Germany

    3 publications · 39 citations

    3

    h-index

1–5 of 220

Institutions

72

  1. Tsinghua University

    Beijing, China

    8 h-index

    37 publications

    2.7K citations

  2. Center for Life Sciences

    Beijing, China

    7 h-index

    31 publications

    2.5K citations

  3. University of Science and Technology of China

    Hefei, China

    7 h-index

    23 publications

    2.1K citations

  4. High Magnetic Field Laboratory

    Hefei, China

    4 h-index

    18 publications

    1.8K citations

  5. University of Wisconsin–Madison

    Madison, United States

    3 h-index

    10 publications

    918 citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    10 publications

    643 citations

  7. Ionis Pharmaceuticals (United States)

    Carlsbad, United States

    3 h-index

    12 publications

    474 citations

  8. University of Tübingen

    Tübingen, Germany

    3 h-index

    10 publications

    127 citations

1–8 of 72

Venues

  1. Journal of the American Chemical Society

    JACS · 6 publications · 598 citations

    6

    h-index

  2. The Journal of Organic Chemistry

    JOC · 3 publications · 97 citations

    3

    h-index

  3. Angewandte Chemie International Edition

    3 publications · 121 citations

    3

    h-index

  4. Chemical Communications

    ChemComm · 2 publications · 68 citations

    2

    h-index

  5. Bioorganic & Medicinal Chemistry

    2 publications · 33 citations

    2

    h-index

1–5