Prothrombin mRNA is expressed by cells of the nervous system

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

Analytical Biochemistry · 1987 · 63.2K citations

Nucleic Acid Chemistry, Engineering, Natural Sciences +7

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

Piotr Chomczyński, Nicoletta Sacchi · Analytical Biochemistry · 1987 · 46.8K citations

Engineering, Natural Sciences, Rna Isolation +7

Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.

Michael A. Frohman, Michael Dush, Gail R. Martin · Proceedings of the National Academy of Sciences · 1988 · 4.6K citations · Full text

Variant Mrnas, Genetics, Molecular Biology +17

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

Rudolph E. Tanzi, Andrea I. McClatchey, Edward D. Lamperti et al. · Nature · 1988 · 1.1K citations

Alzheimer's Disease, Protein Folding, Dementia +12

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

Nobuya Kitaguchi, Yasuyuki Takahashi, Yasuo Tokushima et al. · Nature · 1988 · 1.1K citations

Protease Inhibitory Activity, Alzheimer's Disease, Novel Precursor +11