Journal of Medicinal Chemistry · 2009 · 40 citations · 15 references
Life SciencesMedicinal ChemistryPharmacologyCell SignalingDrug DiscoverySignal TransductionEnzyme InhibitionProtein Kinase CascadesReceptor Tyrosine Kinase SignalingJak InhibitorsJanus Kinase Inhibitor TherapyKinase InhibitorsKinase Signaling InhibitorsProtein Kinase Inhibitors
The synthesis and characterization of a novel polycyclic azaindole based derivative is disclosed, and its binding to JAK2 is described. The compound is further evaluated for its ability to block the EPO/JAK2 signaling cascade in vitro and in vivo.
15
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
Chloé James, Valérie Ugo, Jean‐Pierre Le Couedic et al. · Nature · 2005 · 3.5K citations
A Gain-of-Function Mutation of <i>JAK2</i> in Myeloproliferative Disorders
Róbert Královics, Francesco Passamonti, Andreas Buser et al. · New England Journal of Medicine · 2005 · 3.5K citations · Full text
Life Sciences, Genetics, Hematology +15
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
E. Joanna Baxter, Linda M. Scott, Peter J. Campbell et al. · The Lancet · 2005 · 3.4K citations
Life Sciences, Genetics, Hematology +14