Publication | Open Access
Janus Kinase 2 Inhibitors. Synthesis and Characterization of a Novel Polycyclic Azaindole
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Citations
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References
2009
Year
Molecular PharmacologyMedicinal ChemistryDerivative (Chemistry)BiochemistryMedicineNatural SciencesRational Drug DesignJanus Kinase 2Mechanism Of ActionAnti-cancer AgentClick ChemistryDrug DevelopmentPharmacologyNovel Polycyclic AzaindolePharmaceutical ChemistryDrug Discovery
The synthesis and characterization of a novel polycyclic azaindole based derivative is disclosed, and its binding to JAK2 is described. The compound is further evaluated for its ability to block the EPO/JAK2 signaling cascade in vitro and in vivo.
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