DISTRIBUTION AND CLEARANCE OF CIRCULATING ENDOTOXIN*

Abstract

New Zealand white rabbits weighing 1.9 to 3.5 kg were studied. To produce febrile tolerance, unlabeled endotoxin, 3 to 4 ttg per kg, was given intravenously to one group of animals for five consecutive days before ad- ministration of labeled endotoxin (2). Temperature meas- urements on four rabbits demonstrated definite febrile tolerance after the third injection; therefore it was con- sidered unnecessary to test each animal for tolerance.