ORAI1 deficiency and lack of store-operated Ca2+ entry cause immunodeficiency, myopathy, and ectodermal dysplasia

A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function

Stefan Feske, Yousang Gwack, Murali Prakriya et al. · Nature · 2006 · 2.2K citations

Crac Channel Function, Immunogenetics, Molecular Immunology +10

Orai1 is an essential pore subunit of the CRAC channel

Murali Prakriya, Stefan Feske, Yousang Gwack et al. · Nature · 2006 · 1.3K citations

Protein Secretion, Signal Transduction, Biochemistry +9

X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-κB signaling

Rainer Döffinger, Asma Smahi, Christine Bessia et al. · Nature Genetics · 2001 · 817 citations

Primary Immunodeficiency, Pathogenesis, Immunology +5

Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai

Andriy V. Yeromin, Shenyuan L. Zhang, Weihua Jiang et al. · Nature · 2006 · 796 citations · Full text

Biochemistry, Natural Sciences, Molecular Biology +7

Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance

Masatsugu Oh‐hora, Megumi Yamashita, Patrick G. Hogan et al. · Nature Immunology · 2008 · 584 citations · Full text

T Cell Activation, Molecular Physiology, Signal Transduction +9