Nucleosides and Nucleotides · 1985 · 82 citations · 6 references
Life SciencesBiochemistryMedicinal ChemistryBioisosterismStructure-activity RelationshipsAtp HydrolysisLigand BindingProtein PhosphorylationEnzyme Mechanisms Of Phosphoryl TransferMetal Binding FeaturesMetal-binding PropertiesNucleotide AnalogsNucleotide Analogue SynthesisPhosphonate BioisosteresPhosphonate InhibitorsPhosphoryl Transfer Catalysis
Abstract A range of β,γ-bridged phosphonate analogues of ATP and of β,β-bridged analogues of Ap4A has been synthesised. Some of their metal binding characteristics and inhibition of enzymatic phosphoryl transfer processes can be described in terms of the relative importance of steric and electronic features of the nucleotide analogues.
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J. G. Moffatt, H. G. Khorana · Journal of the American Chemical Society · 1961 · 473 citations
Terrell C. Myers, Kaname Nakamura, Albert Baba. Danielzadeh · The Journal of Organic Chemistry · 1965 · 61 citations
Preston N. Garrison, Larry D. Barnes · Biochemical Journal · 1984 · 37 citations · Full text