Targeting HER2-Positive Breast Cancer with Trastuzumab-DM1, an Antibody–Cytotoxic Drug Conjugate

Gail D. Lewis Phillips, Guangmin Li, Debra L. Dugger, +14

Cancer Research

Drug TargetingBreast OncologyDisulfide LinkersMedicineImmunology +10

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

Ben‐Quan Shen, Keyang Xu, Luna Liu, +30

Nature Biotechnology

ImmunoengineeringImmunologyBioconjugationAntibody EngineeringImmunotherapeutics +6

The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma

Peter D. Senter, Eric L. Sievers

Nature Biotechnology

Tumor BiologyLymphoid NeoplasiaMedicineImmunologyPathology +6

High affinity restricts the localization and tumor penetration of single-chain fv antibody molecules.

Gregory P. Adams, Robert Schier, Adrian M. McCall, +5

PubMed

Tumor PenetrationRadiation OncologyTumor ImmunologyHighest Affinity ScfvImmunology +11

Recommendations for the design and optimization of immunoassays used in the detection of host antibodies against biotechnology products

Anthony R. Mire‐Sluis, Yu Chen Barrett, Viswanath Devanarayan, +11

Journal of Immunological Methods

VaccinationBiotechnology ProductsBioanalysisImmunologyBiotechnology +7

Gemtuzumab Ozogamicin, A Potent and Selective Anti-CD33 Antibody−Calicheamicin Conjugate for Treatment of Acute Myeloid Leukemia

Philip R. Hamann, Lois M. Hinman, Irwin Hollander, +10

Bioconjugate Chemistry

Gemtuzumab OzogamicinImmunologyPharmacotherapyA PotentImmunotherapy +14

Safety, Pharmacokinetics, and Preliminary Clinical Activity of Inotuzumab Ozogamicin, a Novel Immunoconjugate for the Treatment of B-Cell Non-Hodgkin's Lymphoma: Results of a Phase I Study

Anjali S. Advani, Bertrand Coiffier, Myron S. Czuczman, +17

Journal of Clinical Oncology

Novel ImmunoconjugateImmunologyPharmacotherapyMetronomic ChemotherapyRefractory Cd22 +17

<i>In vivo</i>Drug-Linker Stability of an Anti-CD30 Dipeptide-Linked Auristatin Immunoconjugate

Russell J. Sanderson, Michelle A. Hering, Stephanie James, +5

Clinical Cancer Research

Drug TargetingMedicineImmunologyTumor ImmunityImmune Checkpoint Inhibitor +10

Immunogenicity of biologically-derived therapeutics: Assessment and interpretation of nonclinical safety studies

Rafael Ponce, Leslie W. Abad, Lakshmi Amaravadi, +15

Regulatory Toxicology and Pharmacology

AllergyImmunotoxicologyMedicineImmunologyBiologically-derived Therapeutics +8

Modeling analysis of the global and microscopic distribution of immunoglobulin G, F(ab')2, and Fab in tumors.

Kenji Fujimori, David G. Covell, John Fletcher, +1

PubMed

Immunocytochemical TechniqueImmunologyPathologyAntibody DistributionImmunotherapeutics +16