THE CONDUCT OF IN VITRO AND IN VIVO DRUG-DRUG INTERACTION STUDIES: A PHARMACEUTICAL RESEARCH AND MANUFACTURERS OF AMERICA (PhRMA) PERSPECTIVE

Thorir D. Bjornsson, John T. Callaghan, Heidi J. Einolf, +19

Drug Metabolism and Disposition

The Conduct of In Vitro and In Vivo Drug‐Drug Interaction Studies: A PhRMA Perspective

Thorir D. Bjornsson, John T. Callaghan, Heidi J. Einolf, +19

The Journal of Clinical Pharmacology

Drug InteractionsPreclinical Drug EvaluationBiochemistryPharmacological StudyMedicine +12

Strategy for genotoxicity testing—Metabolic considerations

Warren W. Ku, Anita Bigger, Giovanni Brambilla, +8

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

MedicineToxicology TestingGenotoxicity Testing—metabolic ConsiderationsToxicologyExperimental Toxicology +2

Metabolism and Disposition of the HIV-1 Protease Inhibitor Lopinavir (ABT-378) Given in Combination with Ritonavir in Rats, Dogs, and Humans

Gondi Kumar, Venkata Jayanti, Marianne K. Johnson, +10

Pharmaceutical Research

MedicineHuman RetrovirusAntiviral Drug DevelopmentAntiviral TherapyVirology +5

Biological activity and in vivo clearance of anti-tumor antibody/cytokine fusion proteins

Stephen D. Gillies, Delano V. Young, Kin Ming Lo, +1

Bioconjugate Chemistry

Laboratory ImmunologyImmunologyImmunoeditingImmunologic MechanismImmunotherapy +19

Acetaminophen structure-toxicity studies: In vivo covalent binding of a nonhepatotoxic analog, 3-hydroxyacetanilide

Stanley Roberts, Veronica F. Price, David J. Jollow

Toxicology and Applied Pharmacology

Pharmaceutical ScienceAcetaminophen Structure-toxicity StudiesDrug TargetPharmacological StudyBiochemistry +8

Lack of cataleptogenic potentiation with non-imidazole H3 receptor antagonists reveals potential drug–drug interactions between imidazole-based H3 receptor antagonists and antipsychotic drugs

Min Zhang, Michael E. Ballard, Liping Pan, +8

Brain Research

MedicineAntipsychotic DrugsMechanism Of ActionPsychopharmacologyNon-imidazole H3 Receptor +6

The Conduct of In Vitro and In Vivo Drug-Drug Interaction Studies: A PhRMA Perspective

Thorir D. Bjornsson, John T. Callaghan, Heidi J. Einolf, +19

The Journal of Clinical Pharmacology

Drug InteractionsPharmacological StudyBiochemistryMedicineToxicology +6

Considerations for the nonclinical safety evaluation of antibody drug conjugates for oncology

Stanley Roberts, Paul A. Andrews, Diann Blanset, +7

Regulatory Toxicology and Pharmacology

OncologyPolymer-drug ConjugatePharmacologyAntibody EngineeringAnti-cancer Agent +7

Studies on cadmium-induced inhibition of hepatic microsomal drug biotransformation in the rat.

R. Schnell, Jeffrey R. Means, Stanley Roberts, +1

Environmental Health Perspectives

Challenge Cadmium DoseMolecular PharmacologyCadmium-induced InhibitionDrinking WaterHepatology +13