Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.

Matthew F. Krummel, James P. Allison · The Journal of Experimental Medicine · 1995 · 2.2K citations · Full text

Life Sciences, Cell Biology, Immunology +17

The Role of Interleukin (IL)-10 in the Persistence of <i>Leishmania major</i> in the Skin after Healing and the Therapeutic Potential of Anti–IL-10 Receptor Antibody for Sterile Cure

Yasmine Belkaid, Karl F. Hoffmann, Susana Méndez et al. · The Journal of Experimental Medicine · 2001 · 552 citations · Full text

Veterinary Medicine, Immunology, Infectious Diseases +17

Defective IL‐12 production in mitogen‐activated protein (MAP) kinase kinase 3 (Mkk3)‐deficient mice

Hongtao Lu, Derek Yang, Mark Wysk et al. · The EMBO Journal · 1999 · 387 citations · Full text

Life Sciences, Immunology, Pathobiology +16

Selective Suppression of Interleukin-12 Induction after Macrophage Receptor Ligation

Fayyaz S. Sutterwala, Gary J. Noel, Raphael Clynes et al. · The Journal of Experimental Medicine · 1997 · 355 citations · Full text

Life Sciences, Immunology, Molecular Biology +17

Extracellular Signal-Related Kinase (ERK) and p38 Mitogen-Activated Protein (MAP) Kinases Differentially Regulate the Lipopolysaccharide-Mediated Induction of Inducible Nitric Oxide Synthase and IL-12 in Macrophages: <i>Leishmania</i> Phosphoglycans Subvert Macrophage IL-12 Production by Targeting ERK MAP Kinase

Gui-Jie Feng, Helen S. Goodridge, Xiao-Qing Wei et al. · The Journal of Immunology · 1999 · 332 citations

Life Sciences, Immunology, Molecular Biology +17