Concepedia

Lovastatin mediated G1 arrest in normal and tumor breast cells is through inhibition of CDK2 activity and redistribution of p21 and p27, independent of p53

Sharmila Rao, Michael Lowe, Thaddeus W Herliczek, Khandan Keyomarsi

Oncogene · 1998 · 181 citations · 0 references

Concepts

MedicineOncologyPharmacologyCancer PharmacologyCarcinogenesisMolecular OncologyCancer Cell SignalingCell-cycle ArrestCell-cycle DysregulationOncogenic Signaling PathwaysPharmacodynamics Of Anticancer AgentsG1 Cell-cycle ArrestG1 Phase ArrestP21 RegulationP53-mediated ArrestP53-mediated Cell Cycle ArrestP53-mediated Cell Cycle RegulationP53-mediated Cell-cycle Arrest