Hypoxia increases tumor cell sensitivity to glycolytic inhibitors: a strategy for solid tumor therapy (Model C)

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations

Life Sciences, Cell Biology, Molecular Biology +17

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Patrick H. Maxwell, Michael S. Wiesener, Gin-Wen Chang et al. · Nature · 1999 · 5.2K citations

Medicine, Cancer Biology, Oncology +14

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.

Gregg L. Semenza, G.L. Wang · Molecular and Cellular Biology · 1992 · 2.4K citations · Full text

Medicine, Genetics, Molecular Biology +17

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.

GL Semenza, Pinchas Roth, Hui‐Yuan Fang et al. · Journal of Biological Chemistry · 1994 · 1.9K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

Human Cells Lacking mtDNA: Repopulation with Exogenous Mitochondria by Complementation

Michael P. King, Giuseppe Attardi · Science · 1989 · 1.6K citations

Life Sciences, Cell Biology, Molecular Biology +14