E1A-expressing adenoviral E3B mutants act synergistically with chemotherapeutics in immunocompetent tumor models

An Adenovirus Mutant That Replicates Selectively in p53- Deficient Human Tumor Cells

James R. Bischoff, David H. Kirn, Angelica Williams et al. · Science · 1996 · 1.8K citations

Mutant Adenovirus, Adenovirus Mutant, Functional P53 +13

A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

Fadlo R. Khuri, John Nemunaitis, Ian Ganly et al. · Nature Medicine · 2000 · 1.1K citations

Intratumoral Onyx-015, Neck Cancer, Medicine +11

Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3

Natalia Sergina, Megan Rausch, Donghui Wang et al. · Nature · 2007 · 968 citations · Full text

Signal Transduction, Kinase-inactive Her3, Medicine +7

ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

Carla Heise, Adam Sampson-Johannes, Angelica Williams et al. · Nature Medicine · 1997 · 944 citations

Tumor Biology, Cancer-associated Virus, Oncogenic Agent +10

An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy

Carla Heise, Terry Hermiston, Leisa Johnson et al. · Nature Medicine · 2000 · 584 citations

Tumor Biology, Medicine, Adenovirus E1a Mutant +8