The upregulation of dihydropyrimidine dehydrogenase in liver is involved in acquired resistance to 5-fluorouracil

Analyzing real-time PCR data by the comparative CT method

Thomas D. Schmittgen, Kenneth J. Livak · Nature Protocols · 2008 · 26.7K citations

Public Health, Biostatistics, Biomedical Signal Processing +3

A Randomized Phase IIIB Trial of Chemotherapy, Bevacizumab, and Panitumumab Compared With Chemotherapy and Bevacizumab Alone for Metastatic Colorectal Cancer

J. Randolph Hecht, Edith P. Mitchell, Tarek Chidiac et al. · Journal of Clinical Oncology · 2008 · 852 citations · Full text

Medicine, Oncology, Pharmacology +15

Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase.

Dennis Salonga, Kathleen D. Danenberg, Martin R. Johnson et al. · PubMed · 2000 · 834 citations

Medicine, Molecular Biology, Oncology +16

OPTIMOX1: A Randomized Study of FOLFOX4 or FOLFOX7 With Oxaliplatin in a Stop-and-Go Fashion in Advanced Colorectal Cancer—A GERCOR Study

Christophe Tournigand, Andrés Cervantes, Arié Figer et al. · Journal of Clinical Oncology · 2006 · 805 citations

Medicine, Oncology, Pharmacology +15

Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy.

Zhihong Lu, Ruiwen Zhang, Robert B. Diasio · PubMed · 1993 · 374 citations

Medicine, Oncology, Pharmacology +14