Robert B. Diasio

Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase.

Dennis Salonga, Kathleen D. Danenberg, Martin R. Johnson et al. · PubMed · 2000 · 833 citations

Pathology, Thymidylate Synthase, Cancer Biology +18

Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile.

Glen D. Heggie, Jean‐Pierre Sommadossi, David S. Cross et al. · PubMed · 1987 · 731 citations

Oncology, Pharmacology, Clinical Pharmacology +13

Familial deficiency of dihydropyrimidine dehydrogenase. Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity.

Robert B. Diasio, T L Beavers, John T. Carpenter · Journal of Clinical Investigation · 1988 · 499 citations · Full text

Genetics, Toxicological Mechanism, Oxidative Stress +17

Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion.

Barry Harris, Seng-Jaw Soong, Robert B. Diasio · PubMed · 1990 · 445 citations

5-Fluorouracil Levels, Bioanalysis, Toxicology +17

Treatment of Cryptococcal Meningitis with Combination Amphotericin B and Flucytosine for Four as Compared with Six Weeks

William E. Dismukes, Gretchen A. Cloud, Harry A. Gallis et al. · New England Journal of Medicine · 1987 · 415 citations