Four types of fatty acids exert differential impact on pancreatic cancer growth

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.

Gregg L. Semenza, G.L. Wang · Molecular and Cellular Biology · 1992 · 2.4K citations · Full text

Medicine, Genetics, Molecular Biology +17

Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.

Hua Zhong, Angelo M. De Marzo, Erik Laughner et al. · PubMed · 1999 · 2.2K citations

Medicine, Cancer Biology, Oncology +14

Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells

Lisa Pike, Amy Smift, Nicole J. Croteau et al. · Biochimica et Biophysica Acta (BBA) - Bioenergetics · 2010 · 463 citations

Life Sciences, Biochemistry, Pharmacology +17

Direct Transcriptional Up-regulation of Cyclooxygenase-2 by Hypoxia-Inducible Factor (HIF)-1 Promotes Colorectal Tumor Cell Survival and Enhances HIF-1 Transcriptional Activity during Hypoxia

Abderrahmane Kaidi, David Qualtrough, Ann C. Williams et al. · Cancer Research · 2006 · 299 citations · Full text

Medicine, Cancer Biology, Oncology +17

Apoptotic death of pancreatic cancer cells induced by polyunsaturated fatty acids varies with double bond number and involves an oxidative mechanism

R. A. Hawkins, Kathryn Sangster, Mark J. Arends · The Journal of Pathology · 1998 · 148 citations

Life Sciences, Oncology, Pharmacology +15