Concepedia

Discovery and optimization of a series of 2-aminothiazole-oxazoles as potent phosphoinositide 3-kinase γ inhibitors

Yusuke Oka, Tetsuya Yabuuchi, Yasuyuki Fujii, Hidenori Ohtake, Shunichi Wakahara, Kayo Matsumoto, Mayumi Endo, Yunoshin Tamura, Yoshinori Sekiguchi

Bioorganic & Medicinal Chemistry Letters · 2012 · 26 citations · 7 references

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7

Central Role for G Protein-Coupled Phosphoinositide 3-Kinase γ in Inflammation

Emilio Hirsch, Vladimir L. Katanaev, Cecília Garlanda et al. · Science · 2000 · 1.2K citations

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A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

Zachary A. Knight, Beatriz González, Morri E. Feldman et al. · Cell · 2006 · 1.2K citations · Full text

, , +14

Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration

Takehiko Sasaki, Junko Irie-Sasaki, Russell G. Jones et al. · Science · 2000 · 1K citations

, , +17

Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction

Zhong Li, Huiping Jiang, Wei Xie et al. · Science · 2000 · 816 citations

, , +17

Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis

Montserrat Camps, Thomas Rückle, Hong Ji et al. · Nature Medicine · 2005 · 751 citations

, , +15