Cyclooxygenase-1 vs. cyclooxygenase-2 inhibitors in the induction of antinociception in rodent withdrawal reflexes

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

John R. Vane · Nature New Biology · 1971 · 8.6K citations

Aspirin-like Drugs, Prostaglandin Synthesis, Biochemistry +8

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors:  Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1<i>H</i>-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

Thomas D. Penning, John J. Talley, Stephen R. Bertenshaw et al. · Journal of Medicinal Chemistry · 1997 · 1.9K citations · Full text

Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.

Karen Seibert, Y Zhang, K. Leahy et al. · Proceedings of the National Academy of Sciences · 1994 · 1.6K citations · Full text

Pain Medicine, Immunology, Molecular Pain +22

Human cyclooxygenase-2 cDNA.

Timothy Hla, Karen M. Neilson · Proceedings of the National Academy of Sciences · 1992 · 1.5K citations · Full text

Immunology, Cox-2 Transcript, Redox Biology +21

COX-2 inhibitors

The Lancet · 1999 · 1.2K citations