Involvement of glutathione metabolism in the cytotoxicity of the phenethyl isothiocyanate and its cysteine conjugate to human leukaemia cells in vitro11Abbreviations: BSO, l-buthionine sulphoximine; DNP-SG, S-2,4-dinitrophenylglutathione; DTT, dithiothreitol; GST, glutathione S-transferase; HL60, human leukaemia 60; JNK1, c-Jun N-terminal kinase 1; ML-1, human myeloblastic leukaemia-1; PEITC, phenethyl isothiocyanate; PETC, N-phenethylthiocarbamoyl; PETC-Cys, S-(N-phenethylthiocarbamoyl)cysteine; PETC-SG, S-(N-phenethylthiocarbamoyl)glutathione; and Z-VAD-fmk, N-benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone.

Biochemical Pharmacology · 2001 · 124 citations · 38 references