Publication | Closed Access
Second generation analogues of RKA182: synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities
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Citations
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References
2011
Year
Combinatorial ChemistryBioorganic ChemistryAntiparasitic AgentOrganic ChemistryParallel SynthesisChemistryHeterocycle ChemistryExcellent Oral ActivitiesPharmaceutical ChemistryMedicinal ChemistrySynthetic TetraoxanesPolar Dispiro-1,2,4,5-tetraoxanesBiochemistryNatural Product SynthesisPharmacologySecond Generation AnaloguesAntifungal AgentNatural SciencesVivo Antimalarial ActivitiesMedicineDrug Discovery
A series of polar dispiro-1,2,4,5-tetraoxanes have been designed and synthesized by parallel synthesis. From this series, endoperoxides with activity as low as 0.2 nM have been obtained and representatives of this group have excellent oral activities in the P. bergheiANKA mouse model of malaria.
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