PANCREATIC ISLET XENOGRAFT TOLERANCE AFTER SHORT-TERM COSTIMULATION BLOCKADE IS ASSOCIATED WITH INCREASED CD4+ T CELL APOPTOSIS BUT NOT IMMUNE DEVIATION1, 2

Abstract

Combined costimulatory blockade was capable of producing tolerance to pancreatic islet xenografts. The induction of this tolerant state was associated with increased T cell apoptosis, whereas the maintenance phase of tolerance was associated with the accumulation of a large number of inactive lymphocytes within the graft.