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Discovery of (S,E)-3-(2-fluorophenyl)-N-(1-(3-(pyridin-3-yloxy)phenyl)ethyl)-acrylamide as a potent and efficacious KCNQ2 (Kv7.2) opener for the treatment of neuropathic pain

Yong‐Jin Wu, Charles M. Conway, Li‐Qiang Sun, Frederic Machet, Jie Chen, Ping Chen, Huan He, Clotilde Bourin, Vincenzo Calandra, Joseph Polino,

Bioorganic & Medicinal Chemistry Letters · 2013 · 11 citations · 10 references

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An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

Sun Ho Kim, Jin Mo Chung · Pain · 1992 · 3K citations

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The anticonvulsant retigabine attenuates nociceptive behaviours in rat models of persistent and neuropathic pain

Gordon Blackburn-Munro, Bo Jensen · European Journal of Pharmacology · 2003 · 207 citations

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The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels

Bo Hjorth Bentzen, Nicole Schmitt, Kirstine Calløe et al. · Neuropharmacology · 2006 · 92 citations

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Discovery, Synthesis, and Structure–Activity Relationship of a Series of <i>N</i>-Aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener

Haibo Yu, Meng Wu, Steven D. Townsend et al. · ACS Chemical Neuroscience · 2011 · 64 citations · Full text

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( <i>S</i> )- <i>N</i> -[1-(3-Morpholin-4-ylphenyl)ethyl]- 3-phenylacrylamide:  An Orally Bioavailable KCNQ2 Opener with Significant Activity in a Cortical Spreading Depression Model of Migraine

Yong‐Jin Wu, Christopher G. Boissard, Corinne Greco et al. · Journal of Medicinal Chemistry · 2003 · 54 citations · Full text

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