Huan He

Fluorine Substitution Can Block CYP3A4 Metabolism-Dependent Inhibition:  Identification of (<i>S</i>)<i>-N</i>-[1-(4-Fluoro-3- morpholin-4-ylphenyl)ethyl]-3- (4-fluorophenyl)acrylamide as an Orally Bioavailable KCNQ2 Opener Devoid of CYP3A4 Metabolism-Dependent Inhibition

Yong‐Jin Wu, Carl D. Davis, Steven I. Dworetzky et al. · Journal of Medicinal Chemistry · 2003 · 58 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +11

Preparation, Characterization, Pharmacokinetic, and Therapeutic Potential of Novel 6-Mercaptopurine-Loaded Oral Nanomedicines for Acute Lymphoblastic Leukemia

Yaru Zou, Dong Mei, Jinjie Yuan et al. · International Journal of Nanomedicine · 2021 · 35 citations · Full text

Pharmacy, Pharmaceutics, Pharmacology +17

Discovery of (S,E)-3-(2-fluorophenyl)-N-(1-(3-(pyridin-3-yloxy)phenyl)ethyl)-acrylamide as a potent and efficacious KCNQ2 (Kv7.2) opener for the treatment of neuropathic pain

Yong‐Jin Wu, Charles M. Conway, Li‐Qiang Sun et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 11 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +9

Simultaneous quantitative analysis of phosphocreatine, creatine and creatinine in plasma of children by HPLC–MS/MS method: Application to a pharmacokinetic study in children with viral myocarditis

Ning Sun, Qirui Li, Libo Zhao et al. · Biomedical Chromatography · 2019 · 11 citations

Pharmacy, Clinical Pharmacokinetics, Pharmacokinetics +14

Model-Based Meta-Analysis in Psoriasis: A Quantitative Comparison of Biologics and Small Targeted Molecules

Huan He, Wenwen Wu, Yi Zhang et al. · Frontiers in Pharmacology · 2021 · 10 citations · Full text

Medicine, Dermatology, Pharmacology +17