Carl D. Davis

Transient Receptor Potential Melastatin 8 (TRPM8) Channels are Involved in Body Temperature Regulation

Narender R. Gavva, Carl D. Davis, Sonya G. Lehto et al. · Molecular Pain · 2012 · 97 citations · Full text

Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): A potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal delivery

Prasad V. Chaturvedula, Stephen E. Mercer, Sokhom S. Pin et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 60 citations · Full text

Superior Safety Profile, Medicinal Chemistry, Medicine +6

Discovery of TRPM8 Antagonist (<i>S</i>)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine

Daniel B. Horne, Kaustav Biswas, James Brown et al. · Journal of Medicinal Chemistry · 2018 · 60 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Trpm8 Antagonist +15

Discovery of (<i>R</i>)-4-(8-Fluoro-2-oxo-1,2-dihydroquinazolin-3(4<i>H</i>)-yl)-<i>N</i>-(3-(7-methyl-1<i>H</i>-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide (BMS-694153): A Potent Antagonist of the Human Calcitonin Gene-Related Peptide Receptor for Migraine with Rapid and Efficient Intranasal Exposure

Andrew P. Degnan, Prasad V. Chaturvedula, Charles M. Conway et al. · Journal of Medicinal Chemistry · 2008 · 59 citations · Full text

Fluorine Substitution Can Block CYP3A4 Metabolism-Dependent Inhibition:  Identification of (<i>S</i>)<i>-N</i>-[1-(4-Fluoro-3- morpholin-4-ylphenyl)ethyl]-3- (4-fluorophenyl)acrylamide as an Orally Bioavailable KCNQ2 Opener Devoid of CYP3A4 Metabolism-Dependent Inhibition

Yong‐Jin Wu, Carl D. Davis, Steven I. Dworetzky et al. · Journal of Medicinal Chemistry · 2003 · 58 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Pharmaceutical Science +15