Mechanism of Interferon-gamma mediated down-regulation of Interleukin-10 gene expression

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

John David Dignam, Russell M. Lebovitz, R G Roeder · Nucleic Acids Research · 1983 · 11.6K citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +17

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

David Fiorentino, M W Bond, Timothy R. Mosmann · The Journal of Experimental Medicine · 1989 · 2.7K citations

Life Sciences, Cell Biology, Immunology +17

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

René de Waal Malefyt, John B.A.G. Haanen, Hergen Spits et al. · The Journal of Experimental Medicine · 1991 · 1.9K citations · Full text

Life Sciences, Cell Biology, Immunology +15

Enhanced Th1 Activity and Development of Chronic Enterocolitis in Mice Devoid of Stat3 in Macrophages and Neutrophils

Kiyoshi Takeda, Björn E. Clausen, Tsuneyasu Kaisho et al. · Immunity · 1999 · 1.2K citations · Full text

Life Sciences, Immunology, Pathology +16

Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages.

Alexander N. Shakhov, Martine A. Collart, P Vassalli et al. · The Journal of Experimental Medicine · 1990 · 821 citations · Full text

Management, Organization Studies, Organizational Behavior +15