Evaluation of the mutagenic, cytotoxic, and antitumor potential of triptolide, a highly oxygenated diterpene isolated from Tripterygium wilfordii

Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.

Joyce McCann, E Choi, Edna N. Yamasaki et al. · Proceedings of the National Academy of Sciences · 1975 · 3.3K citations · Full text

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Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis

Emily Pisha, Heebyung Chai, Ik‐Soo Lee et al. · Nature Medicine · 1995 · 886 citations

Life Sciences, Medicinal Chemistry, Pharmacology +14

Human Multidrug-Resistant Cell Lines: Increased <i>mdr</i> 1 Expression Can Precede Gene Amplification

Donglai Shen, Antonio Tito Fojo, Janice E. Chin et al. · Science · 1986 · 605 citations

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Tumor inhibitors. LXXIV. Triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii

S. Morris Kupchan, William A. Court, Richard G. Dailey et al. · Journal of the American Chemical Society · 1972 · 510 citations

Medicine, Medicinal Chemistry, Pharmacology +6

Cytotoxic and Antimalarial Bisbenzylisoquinolme Alkaloids from Stephania erecta

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Pharmacy, Medicinal Chemistry, Pharmacology +16