Donglai Shen

Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.

Igor B. Roninson, Janice E. Chin, Kyoung‐Gyu Choi et al. · Proceedings of the National Academy of Sciences · 1986 · 702 citations · Full text

Molecular Biology, Pathology, Tumor Biology +18

Human Multidrug-Resistant Cell Lines: Increased <i>mdr</i> 1 Expression Can Precede Gene Amplification

Donglai Shen, Antonio Tito Fojo, Janice E. Chin et al. · Science · 1986 · 604 citations

Engineering, Mdr1 Mrna, Cancer Biology +17

Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins.

Donglai Shen, Carol Cardarelli, Jinyoung Hwang et al. · Journal of Biological Chemistry · 1986 · 466 citations · Full text

Pathology, Cancer Biology, Tumor Biology +17

Intrinsic drug resistance in human kidney cancer is associated with expression of a human multidrug-resistance gene.

Antonio Tito Fojo, Donglai Shen, Lyn A. Mickley et al. · Journal of Clinical Oncology · 1987 · 224 citations

Intrinsic Drug Resistance, Mdr1-associated Drug Resistance, Cancer Biology +16

Cross-resistance to methotrexate and metals in human cisplatin-resistant cell lines results from a pleiotropic defect in accumulation of these compounds associated with reduced plasma membrane binding proteins.

Donglai Shen, I Pastan, M M Gottesman · PubMed · 1998 · 104 citations

Cisplatin Resistance, Chromatin, Biochemistry +12