Thromboxane A2 activates phospholipase C in astrocytoma cells via pertussis toxin-insensitive G-protein

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

Salvador Moncada, Ryszard J. Gryglewski, S Bunting et al. · Nature · 1976 · 3.6K citations

Medicine, Biochemistry, Pharmacology +16

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

Mats Hámberg, Jan Olof Svensson, B Samuelsson · Proceedings of the National Academy of Sciences · 1975 · 3.1K citations · Full text

Medicine, Pharmacology, Biochemical Pharmacology +14

Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation

Bengt Samuelsson · Science · 1983 · 2.9K citations

Life Sciences, Immunology, Pharmacology +14

Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate

H. Streb, R.F. Irvine, Michael J. Berridge et al. · Nature · 1983 · 2.6K citations

Life Sciences, Cell Biology, Physiology +14