Concepedia

Synthesis and Structure–Activity Relationship Studies of Novel 2-Diarylethyl Substituted (2-Carboxycycloprop-1-yl)glycines as High-Affinity Group II Metabotropic Glutamate Receptor Ligands

Ulrik S. Sørensen, Thomas J. Bleisch, Anne Kingston, Rebecca A. Wright, Bryan G. Johnson, Darryle D. Schoepp, Paul L. Ornstein

Bioorganic & Medicinal Chemistry · 2003 · 25 citations · 24 references

DOI

Concepts

References

24

Unveiling the Functions of Presynaptic Metabotropic Glutamate Receptors in the Central Nervous System

D D Schoepp · Journal of Pharmacology and Experimental Therapeutics · 2001 · 690 citations

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Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4

Yasuto Tanabe, Akihiro Nomura, Masayuki Masu et al. · Journal of Neuroscience · 1993 · 579 citations · Full text

, , +17

Glutamate in CNS disorders as a target for drug development: an update

Chris G. Parsons, Wojciech Danysz, G. Quack · Drug News & Perspectives · 1998 · 447 citations

, , +17

Design, Synthesis, and Pharmacological Characterization of (+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY354740):  A Potent, Selective, and Orally Active Group 2 Metabotropic Glutamate Receptor Agonist Possessing Anticonvulsant and Anxiolytic Properties

James A. Monn, Matthew J. Valli, Steven M. Massey et al. · Journal of Medicinal Chemistry · 1997 · 393 citations

, , +17

LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors

Anne Kingston, Paul L. Ornstein, Rebecca A. Wright et al. · Neuropharmacology · 1998 · 365 citations

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