Concepedia

IL-6 plays an essential role in neutrophilia under inflammation

Misato Hashizume, Yoshinobu Higuchi, Yasushi Uchiyama, Masahiko Mihara

Cytokine · 2011 · 97 citations · 23 references

DOI

Concepts

References

23

Impaired immune and acute-phase responses in interleukin-6-deficient mice

Manfred Köpf, Heinz Baumann, Giulia Freer et al. · Nature · 1994 · 1.8K citations

, , +16

Effect of Neuropeptides on Production of Inflammatory Cytokines by Human Monocytes

Martin Lotz, John H. Vaughan, Dennis A. Carson · Science · 1988 · 923 citations

, , +17

Double‐blind randomized controlled clinical trial of the interleukin‐6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate

Ravinder N. Maini, Peter C. Taylor, Jacek Szechiński et al. · Arthritis & Rheumatism · 2006 · 792 citations

, , +17

Essential Role of Neutrophils in the Initiation and Progression of a Murine Model of Rheumatoid Arthritis

Brian T. Wipke, Paul M. Allen · The Journal of Immunology · 2001 · 590 citations

, , +17

Tocilizumab inhibits signal transduction mediated by both mIL-6R and sIL-6R, but not by the receptors of other members of IL-6 cytokine family

Masahiko Mihara, Keiko Kasutani, Makoto Okazaki et al. · International Immunopharmacology · 2005 · 323 citations

, , +14