The development of benzimidazoles as selective rho kinase inhibitors

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

Masayoshi Uehata, Toshimasa Ishizaki, Hiroyuki Satoh et al. · Nature · 1997 · 2.9K citations

Life Sciences, Biochemistry, Cell Biology +16

Effect of AT877 on cerebral vasospasm after aneurysmal subarachnoid hemorrhage

Masato Shibuya, Yoshio Suzuki, Kenichiro Sugita et al. · Journal of neurosurgery · 1992 · 472 citations

Medicine, Neurological Surgery, Neurosurgery +9

RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis: A mechanism for diabetes-associated erectile dysfunction

Trinity J. Bivalacqua, Hunter C. Champion, Mustafa F. Usta et al. · Proceedings of the National Academy of Sciences · 2004 · 314 citations · Full text

Medicine, Physiology, Urology +14

Intraocular Pressure–Lowering Effects and Safety of Topical Administration of a Selective ROCK Inhibitor, SNJ-1656, in Healthy Volunteers

Hidenobu Tanihara · Archives of Ophthalmology · 2008 · 165 citations

Medicine, Ophthalmology, Pharmacology +15

Development of Dihydropyridone Indazole Amides as Selective Rho-Kinase Inhibitors

Krista Goodman, Haifeng Cui, Sarah E. Dowdell et al. · Journal of Medicinal Chemistry · 2006 · 156 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +17