Ligand-independent oligomerization of TLR4 regulated by a short hydrophobic region adjacent to the transmembrane domain

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

Ruslan Medzhitov, Paula Preston‐Hurlburt, Charles A. Janeway · Nature · 1997 · 5.5K citations

Life Sciences, Immunology, Molecular Biology +13

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors

Adrian Ozinsky, David M. Underhill, Jason D. Fontenot et al. · Proceedings of the National Academy of Sciences · 2000 · 2.1K citations · Full text

Life Sciences, Immunology, Microbiology +17

Unresponsiveness of MyD88-Deficient Mice to Endotoxin

Taro Kawai, Osamu Adachi, Tomohiko Ogawa et al. · Immunity · 1999 · 2.1K citations · Full text

Life Sciences, Immunology, Pathobiology +8

Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 (<i>Tlr4</i>)

Salman T. Qureshi, Line Larivière, Gary Leveque et al. · The Journal of Experimental Medicine · 1999 · 1.5K citations · Full text

Life Sciences, Genetics, Immunology +17

TLR9 signals after translocating from the ER to CpG DNA in the lysosome

Eicke Latz, Annett Schoenemeyer, Alberto Visintin et al. · Nature Immunology · 2004 · 1.3K citations

Life Sciences, Immunology, Molecular Biology +6