Concepedia

The design and synthesis of novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis

Chris De Savi, Andrew R. Pape, John G. Cumming, Attilla Ting, Peter D. Smith, Jeremy N. Burrows, Mark Mills, Chris Davies, Scott G. Lamont, David Milne,

Bioorganic & Medicinal Chemistry Letters · 2011 · 20 citations · 13 references

Open access

Concepts

Medicinal ChemistryPharmaceutical ChemistryAnti-inflammatoryMusculoskeletal ResearchMedicineNovel N-hydroxyformamide InhibitorsOsteoarthritisPharmacological AgentDrug DevelopmentPharmacologyOrthopaedic SurgeryDrug Discovery

References

13

Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

S.S. Glasson, Roger Askew, Barbara Sheppard et al. · Nature · 2005 · 1.2K citations

Mechanobiology, Musculoskeletal Research, Bone Morphogenic Protein +6

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

Heather Stanton, Fraser M. Rogerson, Charlotte J. East et al. · Nature · 2005 · 905 citations

Regenerative Medicine, Major Aggrecanase, Developmental Biology +10

Crystal Structures of Human Cytochrome P450 3A4 Bound to Metyrapone and Progesterone

Pamela A. Williams, José Cosme, Dijana Matak‐Vinković et al. · Science · 2004 · 804 citations

Drug Target, Aldo-keto Reductase, Molecular Biology +16

Cloning and Characterization of ADAMTS11 , an Aggrecanase from the ADAMTS Family

Ilgar Abbaszade, Rui‐Qin Liu, Fude Yang et al. · Journal of Biological Chemistry · 1999 · 486 citations · Full text

Aggrecan Protects Cartilage Collagen from Proteolytic Cleavage

Michael A. Pratta, Wenqing Yao, Carl P. Decicco et al. · Journal of Biological Chemistry · 2003 · 282 citations · Full text