Novel MicroRNA Candidates and miRNA-mRNA Pairs in Embryonic Stem (ES) Cells

Peili Gu, Jeffrey G. Reid, Xiaolian Gao, Chad A. Shaw, Chad J. Creighton, Peter L. Tran, Xiaochuan Zhou, Rafal Drabek, David L. Steffen, David M. Hoang,

PLoS ONE · 2008 · 50 citations · 43 references

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Abstract

Combining expression profile information with miRNA target prediction, we identified miRNA-mRNA pairs that correlate with ES cell pluripotence and differentiation. Perturbation of these pairs in the ES (GCNF(-/-)) mutant suggests a role for miRNAs in the core regulatory networks underlying ES cell self-renewal, pluripotence and differentiation.

References

43