Immortalized cortical neurons expressing caspase-cleaved tau are sensitized to endoplasmic reticulum stress induced cell death

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

Inge Grundke‐Iqbal, Khurshid Iqbal, Y C Tung et al. · Proceedings of the National Academy of Sciences · 1986 · 3.6K citations · Full text

Life Sciences, Neurobiology, Neuroscience +15

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.

K S Kosik, Catharine Joachim, D. J. Selkoe · Proceedings of the National Academy of Sciences · 1986 · 1.5K citations

Life Sciences, Neurobiology, Neuroscience +16

A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity

Thomas Decker, Marie‐Luise Lohmann‐Matthes · Journal of Immunological Methods · 1988 · 1.4K citations

Life Sciences, Biochemistry, Cell Biology +6

Caspase cleavage of tau: Linking amyloid and neurofibrillary tangles in Alzheimer's disease

T. Chris Gamblin, Feng Chen, Ángara Zambrano et al. · Proceedings of the National Academy of Sciences · 2003 · 813 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

The unfolded protein response is activated in Alzheimer’s disease

Jeroen J.M. Hoozemans, Robert Veerhuis, Elise S. van Haastert et al. · Acta Neuropathologica · 2005 · 548 citations

Life Sciences, Molecular Biology, Neuroscience +14