Morphine Tolerance in Spinal Cord Is Due to Interaction between μ- and δ-Receptors

A SIMPLIFIED METHOD OF EVALUATING DOSE-EFFECT EXPERIMENTS

J.T. LITCHFIELD, Frank Wilcoxon · Journal of Pharmacology and Experimental Therapeutics · 1949 · 7.3K citations

Public Health, Biostatistics, Pharmacology +12

Intrathecal morphine in mice: A new technique

Janice L.K. Hylden, George L. Wilcox · European Journal of Pharmacology · 1980 · 1.9K citations

Medicine, Pharmacokinetics, Pharmacology +12

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

Hans W. D. Matthes, Rafaël Maldonado, Frédéric Simonin et al. · Nature · 1996 · 1.7K citations

Medicine, Neuroscience, Pharmacology +17

G-protein-coupled receptor heterodimerization modulates receptor function

Bryen A. Jordan, Lakshmi A. Devi · Nature · 1999 · 1.2K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +12

SIMULTANEOUS QUANTITATIVE ASSESSMENT OF MORPHINE TOLERANCE AND PHYSICAL DEPENDENCE

E. Leong Way, Fu-Hsiung Shen · Journal of Pharmacology and Experimental Therapeutics · 1969 · 680 citations

Medicine, Pharmacokinetics, Pharmacology +10