A strategy for disease gene identification through nonsense-mediated mRNA decay inhibition

Interference of nonsense mutations with eukaryotic messenger RNA stability.

Régine Losson, F. Lacroute · Proceedings of the National Academy of Sciences · 1979 · 477 citations · Full text

Life Sciences, Genetics, Molecular Genetics +15

Wild-type p53 suppresses growth of human prostate cancer cells containing mutant p53 alleles.

William B. Isaacs, Bob S. Carter, Charles M. Ewing · PubMed · 1991 · 439 citations

Medicine, Genetics, Oncology +14

Genetic mapping of a second locus predisposing to hereditary non–polyposis colon cancer

Annika Lindblom, Pia Tannergård, Barbro Werelius et al. · Nature Genetics · 1993 · 437 citations

Life Sciences, Genetics, Molecular Genetics +14

A Regulatory Mechanism That Detects Premature Nonsense Codons in T-cell Receptor Transcripts in Vivo Is Reversed by Protein Synthesis Inhibitors in Vitro

Mark S. Carter, Jessica Doskow, Phillip Morris et al. · Journal of Biological Chemistry · 1995 · 326 citations · Full text

Life Sciences, Genetics, Immunology +17

Rent1, a trans-effector of nonsense-mediated mRNA decay, is essential for mammalian embryonic viability

Susan M. Medghalchi · Human Molecular Genetics · 2001 · 309 citations

Life Sciences, Developmental Biology, Molecular Biology +17