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10-Hydroxy-7,8-dihydropyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-diones: Potent, orally bioavailable HIV-1 integrase strand-transfer inhibitors with activity against integrase mutants

Medicinal ChemistryIntegrase MutantsMedicineNatural SciencesAntiviral Drug DevelopmentAntiviral TherapyMolecular BiologyAntiviral DrugHivPharmacologyAntiviral CompoundDrug DiscoveryDrug Resistance