Experimental Biology and Medicine · 1956 · 16 citations · 0 references
Life SciencesNutritionNutritional SciencesAnimal NutritionCardiovascular PharmacotherapyNutritional BiochemistryAtherosclerosis PharmacotherapyCardiovascular DiseaseCholesterol MetabolismLipid MetabolismLipoprotein AnalysisLipoprotein MetabolismAtherogenic Lipoprotein AssessmentAtherosclerosis RiskAtherosclerotic Cardiovascular Risk ReductionAtherosclerotic Lipid AccumulationDietary CholesterolIntraperitoneal AdministrationPlasma Cholesterol LevelsPotassium Iodide Administration
1. Groups of rabbits were fed a 2% cholesterol diet augmented with 0.001%, 0.01%, 0.1% and 1% potassium iodide, 0.1% diiodotyrosine, and one group received 0.15 mg of thyroxine weekly by intraperitoneal injection. 2. Serum cholesterol and lipoprotein levels of all animals were elevated, but atheromata were significantly reduced in those on diet containing 1% KI. The Sf 0-12 lipoprotein levels were also higher in animals of this group than in controls, but on the whole levels of liver cholesterol were lowest.