Concepedia

PARP1 inhibitors attenuate AKT phosphorylation via the upregulation of PHLPP1

Shuai Wang, Huibo Wang, Ben Davis, Jiyong Liang, Rutao Cui, Sai-Juan Chen

Biochemical and Biophysical Research Communications · 2011 · 20 citations · 23 references

DOI

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23

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

Hannah Farmer, Nuala McCabe, Christopher J. Lord et al. · Nature · 2005 · 6.7K citations

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

Helen E. Bryant, Niklas Schultz, Huw D. Thomas et al. · Nature · 2005 · 5.2K citations

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Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

M. William Audeh, James Carmichael, Richard T. Penson et al. · The Lancet · 2010 · 2.3K citations

, , +16

Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

Geert J.P.L. Kops, Tobias B. Dansen, Paulien E. Polderman et al. · Nature · 2002 · 1.6K citations · Full text

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Poly(ADP)-Ribose Polymerase Inhibition: Frequent Durable Responses in <i>BRCA</i> Carrier Ovarian Cancer Correlating With Platinum-Free Interval

Peter C.C. Fong, Timothy A. Yap, David S. Boss et al. · Journal of Clinical Oncology · 2010 · 992 citations · Full text

, , +17