ChemBioChem · 2008 · 116 citations · 6 references
Life SciencesMolecular BiologyPharmacologyCell SignalingMolecular PharmacologySignal TransductionCyclic Nucleotide SignalingIon Channel PhysiologyIon Channel RegulationIon Channel SignalingIon ChannelsSecond MessengersAbsolute PotencyAdenylate Cyclase SignalingCamp SignalingCamp-protein Kinase A SignalingCyclic Nucleotide-gated Ion ChannelsSecond Messenger Regulation Of Ion ChannelsSignal Transduction By Cyclic Nucleotides
An Epac-selective precursor with high potency: Signalling by the second messenger cAMP is mediated by its receptor proteins protein kinase A (PKA), Epac and cyclic-nucleotide-regulated ion channels. This manuscript describes the synthesis and biological characterisation of a precursor that selectively activates Epac and that is 100 to 1000 times more efficient under biological conditions than the parental compound.
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cAMP Analog Mapping of Epac1 and cAMP Kinase
Anne Elisabeth Christensen, Frode Selheim, Johan de Rooij et al. · Journal of Biological Chemistry · 2003 · 400 citations · Full text