Chemical Communications · 2009 · 63 citations · 9 references
PharmacyBiomedical EngineeringPharmaceuticsBiomedical ImagingCapsule TechnologyDrug DeliveryCapsule FormulationContrast AgentsContrast MediaDrug EncapsulationMagnetic Resonance ImagingNanoparticle FormulationsBiocompatible Encapsulation MaterialsContrast Agent AdministrationDigestionEnzymatic DigestionMagnetic Resonance Imaging Contrast AgentsMicroencapsulation In CapsulesMicroparticle FormulationsMicrosphere Formulations
The exine coatings of spores can be used to encapsulate drug molecules. We have demonstrated that these microcapsules can be filled with a commercial gadolinium(III) MRI contrast agent (in this proof of concept study Gd-DTPA-BMA was used) which is slowly released in plasma due to enzymatic digestion of the capsule.
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