Enhancing liver mitochondrial fatty acid oxidation capacity in obese mice improves insulin sensitivity independently of hepatic steatosis

Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease

Kerry L. Donnelly, Coleman I. Smith, Sarah Jane Schwarzenberg et al. · Journal of Clinical Investigation · 2005 · 3.5K citations · Full text

Life Sciences, Biochemistry, Nutritional Sciences +17

A central role for JNK in obesity and insulin resistance

Jiro Hirosumi, Gürol Tuncman, Lufen Chang et al. · Nature · 2002 · 3.3K citations

Medicine, Biochemistry, Endocrinology +14

Reactive oxygen species have a causal role in multiple forms of insulin resistance

Nicholas Houstis, Evan D. Rosen, Eric S. Lander · Nature · 2006 · 2.5K citations

Life Sciences, Endocrinology, Physiology +13

Triglyceride accumulation protects against fatty acid-induced lipotoxicity

Laura Listenberger, Xianlin Han, Sarah E. Lewis et al. · Proceedings of the National Academy of Sciences · 2003 · 2.1K citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis

Kanji Yamaguchi, Liu Yang, Shannon J. McCall et al. · Hepatology · 2007 · 1K citations · Full text

Life Sciences, Biochemistry, Pharmacology +17