Phenytoin: Pharmacokinetics and bioavailability

R Gugler, Carl V. Manion, Daniel L. Azarnoff

Clinical Pharmacology & Therapeutics

Explanation of dose-dependent decline of diphenylhydantoin plasma levels by fitting to the integrated form of the Michaelis-Menten equation.

Nicholas. Gerber, Wagner Jg

PubMed

Molecular PharmacologyPharmacokinetic ModelingBiochemistryMichaelis-menten EquationMedicine +9

Diphenylhydantoin elimination kinetics in overdosed children

Lorne K. Garrettson, William J. Jusko

Clinical Pharmacology & Therapeutics

Bioavailability and single‐dose pharmacokinetics of intramuscular phenytoin

H.B. Kostenbauder, Robert P. Rapp, J. Patrick McGovren, +5

Clinical Pharmacology & Therapeutics

Phenytoin Plasma ConcentrationsInjection SitePharmacokinetic ModelingPharmacological StudyPharmacology +7

PHENYTOIN DOSE ADJUSTMENT IN EPILEPTIC PATIENTS

G. E. Mawer, Peter W. Mullen, M. Rodgers, +2

British Journal of Clinical Pharmacology

Therapeutic Drug MonitoringPharmacokinetic ModelingPhysiologically-based Pharmacokinetic ModelingNeurophysiologyMedicine +13

Relationship between Dose and Plateau Levels of Drugs Eliminated by Parallel First-Order and Capacity-Limited Kinetics

Tamehiro Tsuchiya, Gerhard Levy

Journal of Pharmaceutical Sciences

Drugs EliminatedPharmacodynamicsHealth SciencesMedicineDrug Discovery +10

Pharmacokinetics of single and multiple doses of phenytoin in man

Lars H. Lund, Gunnar Alván, Anita Berlin, +1

European Journal of Clinical Pharmacology

Pharmacological StudyMultiple DosesPharmacologyNeuropharmacologyPharmacotherapy +3

Bioavailability calculations for drugs showing simultaneous first-order and capacity-limited elimination kinetics

Leo Martis, René H. Levy

Journal of Pharmacokinetics and Biopharmaceutics

Pharmaceutical ScienceCapacity-limited Elimination KineticsBiochemistryBioavailability CalculationsMedicine +6

Bioavailability of diphenylhydantoin

Kenneth S. Albert, Ermelinda Sakmar, Margarette R. Hallmark, +2

Clinical Pharmacology & Therapeutics

Persistent Organic PollutantTherapeutic Drug MonitoringPharmacokinetic ModelingBiochemistryPlasma Levels +12

Bioavailability, Clinical Effectiveness, and the Public Interest

Gerhard Levy

Pharmacology

Preclinical TherapeuticsEvidence-based MedicinePharmacotherapyNew YorkPre-clinical Pharmacology +18