Genetic Polymorphisms in Methylenetetrahydrofolate Reductase and Thymidylate Synthase and Risk of Pancreatic Cancer

A Second Genetic Polymorphism in Methylenetetrahydrofolate Reductase (MTHFR) Associated with Decreased Enzyme Activity

Ilan Weisberg, Pamela V. Tran, Benedicte Christensen et al. · Molecular Genetics and Metabolism · 1998 · 1.3K citations

Biochemistry, Natural Sciences, Genetics +11

A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status

Simonetta Friso, Sang‐Woon Choi, Domenico Girelli et al. · Proceedings of the National Academy of Sciences · 2002 · 925 citations · Full text

Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer.

Jing Ma, Meir J. Stampfer, Edward L. Giovannucci et al. · PubMed · 1997 · 794 citations

Nutrition, Dietary Exposure, Genetic Epidemiology +17

Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy

Sheeja T. Pullarkat, Jan Stoehlmacher, Viviane S. Ghaderi et al. · The Pharmacogenomics Journal · 2001 · 572 citations

Oncogenic Agent, 5-Fu Chemotherapy, Medicine +6

Functional Analysis and DNA Polymorphism of the Tandemly Repeated Sequences in the 5'-terminal Regulatory Region of the Human Gene for Thymidylate Synthase.

Nobuyuki Horie, Hideo Aiba, Katsuhiko Oguro et al. · Cell Structure and Function · 1995 · 549 citations · Full text

Genetics, Genetic Epidemiology, Molecular Biology +18