A molecular signature of metastasis in primary solid tumors

Sridhar Ramaswamy, Ken N. Ross, Eric S. Lander, +1

Nature Genetics

Tumoral PathologyPathologyMolecular SignatureMedicineTumor Microenvironment +1

Estrogen Receptor Status by Immunohistochemistry Is Superior to the Ligand-Binding Assay for Predicting Response to Adjuvant Endocrine Therapy in Breast Cancer

Jennet Harvey, Gary M. Clark, C. Kent Osborne, +1

Journal of Clinical Oncology

A conditional knockout resource for the genome-wide study of mouse gene function

William C. Skarnes, Barry P. Rosen, Anthony P. West, +15

Nature

Knockout MouseFunctional GenomicsGeneticsGenome-wide StudyGene Characterization +11

Edg-1, the G protein–coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

Yujing Liu, Ryuichi Wada, Tadashi Yamashita, +11

Journal of Clinical Investigation

Cell DeathSphingolipid SignalingCellular PhysiologyAngiogenesisAutophagy +18

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

Nitai C. Hait, Jeremy C. Allegood, Michael Maceyka, +8

Science

Lymphocyte Sequestration Through S1P Lyase Inhibition and Disruption of S1P Gradients

Susan R. Schwab, João P. Pereira, Mehrdad Matloubian, +3

Science

ImmunologyImmune RegulationImmunologic MechanismAntigen ProcessingImmunotherapy +19

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

Sergio E. Alvarez, Kuzhuvelil B. Harikumar, Nitai C. Hait, +9

Nature

Missing CofactorProtein FunctionSignal TransductionNatural SciencesMolecular Biology +5

Essential Role for Sphingosine Kinases in Neural and Vascular Development

Kiyomi Mizugishi, Tadashi Yamashita, Ana Olivera, +3

Molecular and Cellular Biology

ApoptosisCell DeathCellular PhysiologyNeuroinflammationNeuroregeneration +18

Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine -1-phosphate therapy

Yutaka Morita, Gloria I. Perez, François Paris, +9

Nature Medicine

Signal TransductionAcid Sphingomyelinase GeneApoptosisSphingosine -1-Phosphate TherapyPathology +7

Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling

Makoto Inoue, Harunor Rashid, Ryousuke Fujita, +3

Nature Medicine

Pain MedicineMedicineNeuropathic PainMolecular PainNeuropharmacology +4