Survival of Resting Mature B Lymphocytes Depends on BCR Signaling via the Igα/β Heterodimer

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

Kirk R. Thomas, Mario R. Capecchi · Cell · 1987 · 2.4K citations

Embryonic Stem Cell, Induced Pluripotent Stem Cell, Developmental Biology +9

Inducible Gene Targeting in Mice

Ralf Kühn, Frieder Schwenk, Michel Aguet et al. · Science · 1995 · 1.9K citations · Full text

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.

Richard R. Hardy, Condie E. Carmack, Susan A. Shinton et al. · The Journal of Experimental Medicine · 1991 · 1.6K citations · Full text

Lymphocyte Development, Genetics, Immunology +19

A<i>cre</i>-transgenic mouse strain for the ubiquitous deletion of<i>loxP</i>-flanked gene segments including deletion in germ cells

Frieder Schwenk, Udo Baron, Klaus Rajewsky · Nucleic Acids Research · 1995 · 1.3K citations

Knockout Mouse, Germ Cell Fate, Transgenic Mouse Models +15

In Vivo Ablation of Surface Immunoglobulin on Mature B Cells by Inducible Gene Targeting Results in Rapid Cell Death

Kong‐Peng Lam, Ralf Kühn, Klaus Rajewsky · Cell · 1997 · 1.1K citations · Full text

Vivo Ablation, Mature B Cells, Apoptosis +8